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KMID : 1101020170420010020
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Journal of Oral Medicine and Pain
2017 Volume.42 No. 1 p.20 ~ p.24
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Drug-induced Gingival Overgrowth Related to Sirolimus and Felodipine
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Park Youn-Jung
Lee Joo-Hee
Kim Young-Gun
Kwon Jeong-Seung
Ahn Hyung-Joon
Choi Jong-Hoon
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Abstract
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Drug-induced gingival overgrowth (DIGO) is an adverse drug reaction mainly described withthree types of commonly prescribed drugs, namely, calcium channel blockers (CCBs) (nifedipine,diltiazem, and verapamil), anti-convulsants (phenytoin), and immunosuppressive agents (cyclosporine). Numerous reports have associated gingival overgrowth with the newer generationof immunosuppressive agents (tacrolimus, sirolimus, and everolimus), and CCBs (amlodipine,felodipine, nicardipine, and manidipine). Especially, patients concomitantly medicated with animmunosuppressive agent and CCB have a higher DIGO chance. Dentists need to be aware ofdrugs that induce gingival overgrowth, the possibility of DIGO, and risk factors, and also preventthe progression of DIGO by early detection of DIGO, consultation about the drug change,and the maintenance of strict dental hygiene regimes.
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KEYWORD
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Calcium channel blockers, Gingival overgrowth, Immunosuppressive agents
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